Download A world-wide yearly survey of new data and trends in adverse by J.K. Aronson (Eds.) PDF

By J.K. Aronson (Eds.)

ISBN-10: 0444509992

ISBN-13: 9780444509994

The negative effects of gear Annual used to be first released in 1977. it's been released always considering then, as a each year replace to the encyclopaedic quantity Meyler's negative effects of gear. each one new Annual presents clinicians and clinical investigators with a competent and important every year survey of recent information and developments within the quarter of difficult Drug Reactions and Interactions.

a world crew of experts have contributed to the Annuals via determining significantly from each one year's guides all that's really new and informative, by means of severely examining it, and through mentioning no matter what is deceptive. using the publication is more suitable through separate indexes, permitting the reader to go into the textual content through the drug identify, opposed influence, or drug interaction.

designated beneficial properties of the Annuals are the uncomfortable side effects of substances Essay, often written by way of a visitor writer, and the particular reports: brief articles, in the diverse chapters, that supply additional realization to themes of present interest.

The Essay in Annual 26 is entitled 'How secure is cannabis?' (by Professor L.L. Iversen) and there's a ancient Essay entitled 'From thalidomide to pharmacovigilance: a private account' (by Professor D.J. Finney).

The precise reports during this quantity contain, between others:

  • The cognitive results of Ecstasy
  • Antipsychotic medicines and weight gain
  • Vigabatrin-related visible abnormalities
  • Managing the adversarial results of morphine
  • The cardiotoxic results of antihistamines
  • Inhaled corticosteroids and development inhibition in children
  • Bioterrorism and its prevention via immunization

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Extra resources for A world-wide yearly survey of new data and trends in adverse drug reactions

Example text

The behavioral and organ changes were similar in monkeys, but less severe than those seen in rats. Further studies were carried out to assess the damage that might be done to the developing fetus by exposure to cannabis or cannabinoids during pregnancy. Treatment of pregnant rabbits with THC at doses up to 5 mg/kg had no effect on birth weight and did not cause any abnormalities in the offspring (10ER ). A similarly detailed toxicology study was carried out with THC by the National Institute of Environmental Health Sciences in the USA, in response to a request from the National Cancer Institute (11E ).

Testing for adverse reactions using Prescription Event Monitoring. Stat Med 1996; 15: 987–1002. 30. Napke E. Drug Adverse Reaction Alerting Program. Can Pharm J 1968; 29: 251–4. 31. Patwary KW. Report on Statistical Aspects of the Pilot Project for International Drug Monitoring. Geneva: World Health Organization, 1969. 32. Finney DJ. Systematic signalling of adverse reactions to drugs. Methods Inf Med 1974; 13: 1–10. 33. Finney DJ. The detection of adverse reactions to therapeutic drugs. Stat Med 1982; 1: 153–61.

Whether this is relevant to the so-called “gateway” theory is unclear. In the US National Household survey of Drug Abuse respondents aged 22 years or over who had started to use cannabis before the age of 21 years were 24 times more likely than non-cannabis users to begin using hard drugs (114C ). However, in the same survey the proportion of cannabis users who progressed to heroin or cocaine use was very small (2% or less). Mathematical modelling using the Monte Carlo method suggested that the association between cannabis use and hard drug use need not be causal, but could relate to some common xli How safe is cannabis?

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