By Deepak L. Bhatt, Anthony A Bavry
Acute coronary syndromes (ACS) is an umbrella time period used to explain a sequence of signs indicative of myocardial ischemia, comprising risky angina, non-ST section elevation myocardial infarction, and ST section elevation myocardial infarction.
Managing Acute Coronary Syndromes in medical perform is a vital source for the clinician within the administration of ACS. as well as supplying a complete evaluate of the epidemiology and medical presentation of ACS, it additionally publications the reader via danger evaluation, probability stratification, analysis, and therapy of ACS. The ebook concludes with a dialogue on rising applied sciences within the therapy of ACS. The guide layout and plentiful use of illustrations make this pocketbook a good source for normal Practitioners, Emergency drugs Physicians, Nurses, Nurse Practitioners, Pharmacists, health practitioner Trainees, clinical scholars, Nursing scholars, and Paramedics who desire to retain updated with contemporary advances within the figuring out and therapy of ACS.
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Additional info for Acute Coronary Syndromes in Clinical Practice
Bavry AA, Mood GR, Kumbhani DJ, et al. Long-term benefit of statin therapy initiated during hospitalization for an acute coronary syndrome: a systematic review of randomized trials. Am J Cardiovasc Drugs 2007; 7:135–141. Chapter 5 Anti-platelet therapies Anti-platelet drugs are one of the fundamental therapies for improving cardiovascular outcomes among ACS patients. Medications are used adjunctively along with mechanical or chemical reperfusion. Patients who are not candidates for revascularization may only receive medical treatment for their ACS.
Low-molecular-weight heparin Low-molecular-weight heparin has a narrower range of sizes of polysaccharide molecules with a mean weight of approximately 5000 Daltons. There are pharmacological advantages of a low-molecular-weight heparin over unfractionated heparin. These include less platelet activation, predictable absorption with subcutaneous administration, and less heparin-induced thrombocytopenia. Low-molecular-weight heparin does not require monitoring except in special circumstances such as pregnancy or perhaps marked renal dysfunction, in which case anti-Xa levels can be monitored.
75–162 mg/day) should be used long term to minimize bleeding complications. New guidelines recommend aspirin 162–325 mg/day among patients who receive a coronary stent (3 months for a sirolimus stent and 6 months for a paclitaxel stent), then decrease to 75–162 mg/day [4,6]. The use of ibuprofen is discouraged due to an interaction with aspirin; however, if this medicine is used it should be given at least 8 hours before or 30 minutes after the administration of aspirin . Reproduced with permission from Peters et al.